Technologies

Our development and production processes are guided by the integrated TTQS system – Truffini Total Quality System, that ensures products are safe, effective, stable and appreciated by end consumers.

Icon TTQS TOTAL QUALITY SYSTEM TRUFFINI

We use innovative and advanced technologies, some of them patented by us, that allow us to produce products that are unique and with particular characteristics:

  • Precise control of the release of active ingredients
  • Product stability over time
  • Improved taste

Innovation is a fundamental value for us at Truffini & Reggè.

Over the years we have developed several advanced technologies for improving production processes and the efficacy of our products.

SWALLOWABLE TABLETS
Gastroresistant Lipidic
Matrix Tablets T-MatrixLipid
Multilayer Advanced Release
System Tablet MultiArs
Jellifying Fast Release Matrix Jelly-F-Matrix
Hydro-Lipophylic Matrix IdrOil-Matrix
Jellifying Tablets Jelly-F-Tab
Health Color System HCS
Hydro-Lipophylic Matrix
T-MatrixLipid Features
  • Monolayer swallowable tablets
Uses
  • Applicable in swallowable tablets ranging from 50 mg to 1.4 g
  • Technology for slow physiological release of active ingredients
Benefits
  • Protection of active principles sensitive to gastric pH
  • Enhanced absorption of non-water-soluble actives: improved product efficacy
Multilayer Advanced Release System Tablet
MultiArs Features
  • Multilayer tablets (2-3 layers)
  • Film-coated multilayer tablets with breakble line
Uses
  • Separation of active ingredients
  • Separation of active principles into fast and slow layers
  • Easy swallowing
Benefits
  • Prevented incompatibility of active ingredients
  • Promoted controlled and optimized release for each active component
  • Improved patient compliance
Jellifying Fast Release Matrix
Jelly-F-Matrix Features
  • Tablet with rapid disaggregation of gelling ingredients (alginates, glucomannan, chitosan, etc.)
Uses
  • Raft effect: barrier effect against the rise of gastric contents into the esophagus
Benefits
  • Immediate relief of symptoms
  • Better absorption of active ingredients at the gastric level
  • Prolonged effect
Jelly-F-Tab Features
  • Hydratable tablet technology with highly gelling polymers and excipients
  • Assumption via special dispensing spoon
Uses
  • Easier administration suitable for everyone: the tablet turns into a soft mousse
  • Target population includes those with dysphagia, pediatric and geriatric patients
  • Film-forming action on the orobuccal and esophageal epithelium
  • Wide therapeutic versatility: GERD, URTI, oral cavity, and bedtime mousse
Benefits
  • Improved patient compliance due to facilitated intake and tablet pleasantness
  • Reduced sugar intake
Hydro-Lipophylic Matrix
IdrOil-Matrix Features
  • Incorporation of lipophilic and oily agents into a granulate
Uses
  • For pharmaceutical forms with active oily (capsules, granules, tablets)
  • For granulates with amphoteric properties. (hydrophilic outer coating)
Benefits
  • Increased bioavailability and intestinal absorption of lipophilic actives
  • Ad hoc formulations for Irritable Bowel Syndrome (IBS)
  • Ad hoc formulations for URTI to deliver balsamic essential oils
Health Color System
HCS Features
  • Is a system for choosing colors of tablets and capsules based on the physological effect of colors allows to choose the color synergistic to the products effect
  • 65 color samples created with legally approved, longlasting pigments of proven safety
ODT AND CHEWABLE TABLETS
Optimized Orobuccal Release
tablet Oro-F-Release
Fast-Slow Optimized Orobuccal Release Tablet Oro-FS-Release
Effervescent Orobuccal Release Tablet Oro-Eff-Release
Orobuccal Palatable Acid
System Buffered OroPAS H+
Chocolate Coating For
Chewable Tablets Cho-Cover
Cocoa Matrix For
Chewable Tablets ChocoMatrix + TM
Optimized Orobuccal Release tablet
Oro-F-Release Features
  • Tablets and orodispersible stick-packs
Uses
  • Pharmaceutical form that is convenient and suitable for everyone
  • Rapid release of active ingredients into the oral cavity
Benefits
  • Improved patient compliance
  • Excellent palatability
  • Ideal for acid actives such as SAMe
  • No water required for the intake
  • Proven absorption efficacy
  • High bioavailability of active ingredients
Fast-Slow Optimized Orobuccal Release Tablet
Oro-FS-Release Features
  • Bilayer Orodispersible Tablets with fast and slow release
  • Orodispersible Tablets with fast release layer and slow release granules
Uses
  • Practical pharmaceutical form suitable for everyone
  • Ideal for hygroscopic actives (such as SAMe, GSH, etc.)
  • Site-specific release of actives:
    • Oro-buccal (fast) release for actives that can be absorbed through the oral mucosa
    • Enteric (slow) release for other actives
Benefits
  • Improved patient compliance (excellent palatability, no need for water during administration)
  • Demonstrated absorption efficacy
  • High bioavailability for actives:
    • Targeting Central Nervous System
    • Susceptible to first-pass hepatic metabolism
    • Affected by gastric pH
Effervescent Orobuccal Release Tablet
Oro-Eff-Release Features
  • Orodispersible tablets with mild effervescence
Uses
  • Pharmaceutical form that is convenient and suitable for everyone (Ideal for those who play sports and cannot drink water)
  • Rapid release of active ingredients in the oral cavity
Benefits
  • Improved patient compliance (No water required for intake)
  • Proven absorption efficacy
  • Preferential absorption of actives that act on Central Nervous System
  • Rapid absorption of actives reduces hepatic inactivation
Orobuccal Palatable Acid System Buffered
OroPAS-H+ Features
  • Granulates (stick-packs, sachets), orosoluble and chewable tablets
Uses
  • Ideal for acid active ingredients (SAMe)
  • Ideal for masking the unpleasant taste of acid actives
Benefits
  • Improved patient compliance: improved the palatability of acid actives
Chocolate Coating For Chewable Tablets
Cho-Cover Features
  • Chocolate-covered chewable tablets
Uses
  • Pharmaceutical form that is convenient and suitable for everyone, even for children
  • Chocolate coating ideal for lipophilic actives
Benefits
  • Improved patient compliance
  • Good protection of actives guaranteed
  • Taste-masking effect (excellent palatability - ideal for actives with an unpleasant taste)
Cocoa Matrix For Chewable Tablets
ChocoMatrix Features
  • Chewable tablets with an exclusive blend of cocoa powder and paste
  • Sugar, gluten and lactose free
Uses
  • Convenient pharmaceutical form suitable for everyone, including pediatric and diabetic use
  • Technology allows for high amounts of lipophilic ingredients to be incorporated
Benefits
  • Improved patient compliance
  • Suitable for those following a low-sugar, gluten-free, lactose-free, and vegan diet
  • Optimized absorption of lipophilic actives (EFSA opinion ID 670, 2902)
  • Taste-masking effect (excellent palatability – ideal for actives like iron pyrophosphate)
POWDER & LIQUID-FILLED CAPSULES
Gastroresistant Liquid Filled
Capsules Gastro-R-Oilcaps
Gastroresistant Liquid Filled
Capsules Vegan Gastro-R-OilcapsV
Colon Release Powder Filled
Capsules ColonPW-Caps
Colon Release Liquid Filled
Capsules Colon-Oilcaps
The Capsule To Dissolve
In Your Drink TeasyBoost-C
Gastroresistant Lipidic
Matrix Granulation G-Matrix-Lipid
Gastroresistant Liquid Filled Capsules
Gastro-R-Oilcaps Features
  • Film-coated animal gelatin hard capsules gastroprotected and filled with oily ingredients
Uses
  • Enteric release of lipophilic actives (gastroprotection)
Benefits
  • Improved patient compliance
  • Improved patient compliance (absence of regurgitation)
  • Controlled release of actives
  • High bioavailability and absorption Of the lipophilic actives
Gastroresistant Liquid Filled Capsules Vegan
Gastro-R-OilcapsV Features
  • Film-coated gastroprotected vegetable hard capsules and filled with oily ingredients
Uses
  • Enteric release of lipophilic actives (gastroprotection)
  • Formulations suitable for vegan consumers
Benefits
  • Improved patient compliance (absence of regurgitation)
  • Controlled release of actives
  • High bioavailability and absorption of lipophilic actives
Colon Release Powder Filled Capsules
ColonPW-Caps Features
  • Film-coated animal gelatin hard capsules gastroprotected and filled with powders
Uses
  • Colonic release of actives (gastroprotection)
Benefits
  • Improved patient compliance
  • Controlled release of actives
  • High bioavailability and absorption Of liphofilic actives ( absorption after 4-5 hours)
Colon Release Liquid Filled Capsules
Colon-Oilcaps Features
  • Film-coated animal gelatin hard capsules gastroprotected and filled with oily ingredients
Uses
  • Colonic release of lipophilic actives (gastroprotection)
Benefits
  • Improved patient compliance (no regurgitation)
  • Controlled release of actives
  • High bioavailability and absorption Of liphofilic actives (absorption after 4-5 hours)
The Capsule To Dissolve In Your Drink
TeasyBoost-C Features
  • Gelatin capsules
Uses
  • Capsule to be dissolved in a hot beverage with a watery (tea, coffee, herbal teas, infusions, chocolate, milk)
Benefits
  • Enrichment of your favorite beverage (boost effect) without altering the flavor
  • Suitable for gluten-free and lactose-free diet
  • Clean label formulations: with few excipients, free of dyes, sweeteners and flavorings
Hydro-Lipophylic Matrix
G-Matrix-Lipid Features
  • Gastroprotected coating for granules and powders
Uses
  • Technology for slow physiological release of actives
Benefits
  • Protection of active ingredients sensitive to gastric pH
  • Optimized intestinal absorption of non-water-soluble actives: improved the efficacy of the product
SACHETS & STICK-PACK
Powder Multisachet Technology MultiPW-Pack
Powder Multisachet Technology MultiPW-Pack
Low Moisture Stick-Pack
Technology Dry-SP-System
Low Moisture Stick-Pack Technology Easy Open Open-SP-System
Gastroresistant Lipidic
Matrix Granulation G-Matrix-Lipid
Orobuccal Palatable Acid
System Buffered OroPAS H+
Truffini Probiotics System Truffini Probiotics System
Jellifying Granules Jelly-F-Stick
The Sachet To Dissolve
In Your Drink TeasyBoost-S
Powder Multisachet Technology
MultiPW-Pack Features
  • Sachets that can be divided into 2 separate chambers, filled with different powders (A-B)
Uses
  • Formulations with incompatible active ingredients with each other (E.g., probiotics+cranberry)
  • For patients who swallow with difficulty (dysphagia/elderly)
Benefits
  • Improved stability of the finished product
  • Easier intake by the patient
Tecnologia bustina multicamera riempita con polveri
MultiPW-Pack Features
  • Sachets that can be divided into 2 or more separate chambers, filled with the same powders (A-A)
Uses
  • Formulations requiring multiple dosages To be divided throughout the day
  • For patients who swallow with difficulty (dysphagia/elderly)
Benefits
  • Chronotherapy
  • Facilitate multiple daily administrations in one (4 to 6 sachets in one)
Low Moisture Stick-Pack Technology
Dry-SP-System Features
  • Stick-pack filled in extremely low-humidity environments
  • Use of high-protection aluminum
  • Stick-pack with either orally soluble or water-dispersiblegranules
  • Stick-pack with coplanar sealing
Uses
  • Ideal for formulations containing hygroscopic active ingredients(such as SAMe, probiotics)
  • Suitable for patients who have difficulty swallowing dysphagia/elderly) or for athletes
  • Convenient and practical to carry around
Benefits
  • Enhanced the quality and stability of the finished product (excellent protection for active ingredients)
Low Moisture Stick-Pack Technology Easy Open
Open-SP-System Features
  • Stick-pack with orosoluble or water-dispersible granulates and powders
  • Stick-pack with coplanar sealing
Uses
  • For patients who swallow with difficulty (dysphagia/elderly) or for athletes
  • Convenient and practical to carry around
Benefits
  • Improved quality and stability of the finished (excellent protection of active ingredients)
Truffini
Truffini Features
  • Granulates (stick-packs, sachets) and tablets (orosoluble, chewable and swallowable)
  • Stability studies in partership with strain manufacturer
Uses
  • Probiotic-based formulations
  • Possibility of developing stand-alone or co-formulated products (e.g., probiotics+cranberry)
Benefits
  • Excellent palatability of stick and sachet formulations
  • Excellent stability of strains until the end of shelf-life
  • Formulations with very few excipients
FOR MORE INFORMATION
Jelly-F-Stick
Jelly-F-Stick Features
  • Granulates (stick-packs) with rapid disaggregation of gelling ingredients (alginates, glucomannan, chitosan, etc.)
Uses
  • Raft effect: barrier effect against rising of gastric contents into the esophagus
Benefits
  • Immediate relief of symptoms
  • Better absorption of active ingredients at the gastric level
  • Prolonged effect
The Sachet To DissolveIn Your Drink
TeasyBoost-S Features
  • Granulates in stick-pack
Uses
  • Granulates to be dissolved in an water-based beverage or added in yogurt
Benefits
  • Enrichment of your favorite beverage/yogurt (boost effect) without altering the flavor
  • Suitable for gluten-free and lactose-free diet
  • Clean label formulations : few excipients, free of dyes, sweeteners and flavorings
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